Generic Drug Name Stems Cheat Sheet. If you are studying nursing pharmacology, a great way of understanding and memorizing the use and function of medication is to familiarize yourself with its generic name stem. Usually, drugs of the same therapeutic class are given names with the same stem. These stems are mostly placed …The Medication Safety - Practice Guidelines and Tools is written to serve as a reference tool for all healthcare professionals, not limited but especially for doctors, pharmacists, nurses and patient support staff. A softcopy of the Guide can be downloaded here. Ministry of Health (MOH) is an innovative, people-centred organisation, committed ...240-672-8872. Consumer: 888-INFO-FDA. The FDA proposed a new, easy-to-read Medication Guide for patients. Patient Medication Information would provide patients with clear, concise, accessible and ...U.S.-based MDs, DOs, NPs and PAs in full-time patient practice can register for free access to the Prescribers’ Digital Reference on PDR.net. PDR.net is to be used only as a reference aid, it is not intended to be a substitute for the exercise of professional judgement. Few Young Adults Could Administer Naloxone to Reverse Fentanyl Overdose. Drugs.com is the most popular, comprehensive and up-to-date source of drug information online. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines & natural products. April Hazard Vallerand, Cynthia A Sanoski. F.A. Davis, May 18, 2020 - Medical - 1488 pages. Davis’s Drug Guide for Nurses®, Seventeenth Edition delivers all the information you need to administer medications safely across the lifespan—well-organized monographs for hundreds of generic and thousands of trade-name drugs.Treatment is indicated in patients with Paget’s disease of bone with elevations in serum alkaline phosphatase of two times or higher than the upper limit of the age-specific normal reference range, or those who are symptomatic, or those at risk for complications from their disease [see Clinical Studies (14.5)].Store ELIQUIS at room temperature between 68°F to 77°F (20°C to 25°C). Keep ELIQUIS and all medicines out of the reach of children. General Information about ELIQUIS. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use ELIQUIS for a condition for which it was not prescribed.Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side …Metoprolol is available as two different salts: metoprolol tartrate and metoprolol succinate. The main difference between metoprolol tartrate and metoprolol succinate is that metoprolol tartrate is only available as an immediate-release tablet which means it must be taken several times per day, whereas metoprolol succinate is an … Decrease in abdominal girth and weight. Increase in urinary output. Decrease in BP. Find information on Furosemide (Furoscix, Lasix) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Aug 22, 2023 · feeling dizzy, light-headed, tired, or very weak; stomach pain, vomiting; or. slow or irregular heart rate. Common metformin side effects may include: low blood sugar; nausea, upset stomach; or. diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question.Find information on Donepezil (Adlarity, Aricept) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Sep 18, 2023 · A Medication Guide is patient labeling that is part of the FDA-approved prescription drug labeling for certain prescription drugs when the FDA determines that: Patient adherence to directions for ... Aug 9, 2022 · Search FDA Approved Drugs on Drugs@FDA. Explore the database to find drug labels (package inserts), generics, patient information, FDA review and approval history. Find information on Diazepam (Diastat, Valium) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Insulin is a naturally occurring hormone secreted by your pancreas. If you are prescribed insulin, it may be because your body doesn’t produce it (type 1 diabetes) or your body doesn’t use it properly (type 2 diabetes). There are many different types of insulin sold in the United States, which differ in how they’re made, how they work in ...DrugGuide.com, the online companion to Davis’s Drug Guide, provides trusted, easy-to-search content on the web. Search over 1,700 drug monographs and over 5,000 trade …If you or someone else needs urgent help after taking drugs or drinking, call 999 for an ambulance. Tell the crew everything you know. It could save their life. What else to do in an emergency. 0300 1236600. Find out everything you need to know about drugs, their effects and the law. Talk to Frank for facts, support and advice on drugs and ... Davis’s Drug Guide for Nurses®, Eighteenth Edition delivers everything you need to administer medications safely across the lifespan— 643 well-organized monographs encompassing hundreds of generic drugs and thousands of trade names. Its nursing-focused ‘Cure & Care’ ‘Cure’ approach makes it the ideal resource for both student and ... Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF. Find information on Ondansetron (Zuplenz) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Try the app for 14 days! INSTALL. Skip to main content navigation Skip to main content.By Madison Malone Kircher. April 19, 2024, 12:10 p.m. ET. When Taylor Swift released “The Tortured Poets Department,” on Friday at midnight, her fan base quickly …Davis's Drug Guide is a comprehensive and practical resource for drug information on over 5,000 trade names and generic drugs. It includes dosing calculators, pill pictures, safety …Use WebMD’s Pill Identifier to find and identify any over-the-counter or prescription drug, pill, or medication by color, shape, or imprint and easily compare pictures of multiple drugs.Davis's Drug Guide for Nurses provides comprehensive, current drug information in well-organized, nursing-focused monographs. It also includes extensive supplemental …The Medication Safety - Practice Guidelines and Tools is written to serve as a reference tool for all healthcare professionals, not limited but especially for doctors, pharmacists, nurses and patient support staff. A softcopy of the Guide can be downloaded here. Ministry of Health (MOH) is an innovative, people-centred organisation, committed ...In acute care settings, nurses frequently administer medications via the intravenous (IV) route. Medications may be administered through a primary line that is already infusing fluids or through a saline lock inserted into a patient’s vein with direct access to the bloodstream. Medications given via the IV route enter the bloodstream immediately, so extreme …Guidelines for Prescription Medicines. The Australian Regulatory Guidelines for Prescription Medicines (ARGPM) assist applicants and sponsors to register new prescription medicines or vary existing registrations in Australia. Sponsors may now apply to register a prescription medicine under the provisional approval pathway, priority review ...TikTok’s Crackdown on Ozempic Influencers Threatens Weight-Loss Drug Hype Machine. Creators say the rules are unfair and harmful to their businesses. TikTok …Davis’s Drug Guide for Nurses, Eighteenth Edition, always puts safety first, emphasizing the medical information nurses need to know to administer medications competently and safely. Today’s most comprehensive nursing drug guide contains well-organized monographs for thousands of generic and trade name drugs reflecting the …Acknowledgments. We offer our thanks to the students and nurses who have used our book for more than 35 years. We hope our book provides you with the current knowledge of pharmacotherapeutics you need to continue to give quality care in our rapidly changing health care environment. April and Cindy.Final statements are developed by consensus decision making. Institute for Safe Medication Practices. 5200 Butler Pike. Plymouth Meeting, PA 19462. (215) 947-7797. ISMP Medication Safety Guidelines cover a variety of topics, including the safe use of technology, specific high-alert medications, and treating high-risk patient populations.Find information on Pantoprazole (Protonix) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Try the app for 14 days! INSTALL. Skip to main content navigation Skip to main content.The ICH Harmonised Guideline was finalised under Step 4 in November 1996. This document is an annex to the main stability Guideline, and gives guidance on the basic testing protocol required to evaluate the light sensitivity and stability of new drugs and products. Date of Step 4: 6 November 1996. Status: Step 5.PO (Adults): Phentermine 3.75 mg/topiramate 23 mg once daily for 14 days, then ↑ to phentermine 7.5 mg/topiramate 46 mg once daily for 12 wk, then assess weight loss. If patient has not lost at least 3% of baseline body weight, ↑ dose to phentermine 11.25 mg/topiramate 69 mg once daily for 14 days, then phentermine 15 mg/topiramate 92 mg ...Davis's Drug Guide for Nurses provides comprehensive, current drug information in well-organized, nursing-focused monographs. It also includes extensive supplemental material in 14 appendices, addresses the issue of safe medication administration, and educates the reader about 45 different therapeutic classes of drugs.Route/Dosage. PO (Adults): 1 mg 3 times daily initially; ↑ by 1 mg every 2–3 days until desired response, usual effective dose is 3–6 mg/day in divided doses (up to 12 mg/day has been used); if insomnia occurs, evening dose may be ↓. IM (Adults): Initiate with a 5–20 mg test dose (use 5 mg dose in elderly/frail/cachectic patients) as ...Common methylprednisolone side effects may include: fluid retention (swelling in your hands or ankles); dizziness, spinning sensation; changes in your menstrual periods; headache; mild muscle pain or weakness; or. stomach discomfort, bloating. This is not a complete list of side effects and others may occur.Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Sertraline (Zoloft) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Washington State University researchers have been awarded more than $370,000 for a two-year study into the impact of a controversial drug administered to … Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF. Find information on Fluoxetine (PROzac, Sarafem) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Final statements are developed by consensus decision making. Institute for Safe Medication Practices. 5200 Butler Pike. Plymouth Meeting, PA 19462. (215) 947-7797. ISMP Medication Safety Guidelines cover a variety of topics, including the safe use of technology, specific high-alert medications, and treating high-risk patient populations.Medication Guide Prolia® (PRÓ-lee-a) (denosumab) Injection, for subcutaneous use What is the most important information I should know about Prolia? If you receive Prolia, you should not receive XGEVA®Common clonidine side effects may include: drowsiness, dizziness; feeling tired or irritable; dry mouth; constipation, loss of appetite; or. sleep problems ( insomnia ), nightmares. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.Action. Acts as a peripheral dopamine receptor blocker. Increases GI motility, peristalsis, and lower esophageal sphincter pressure. Facilitates gastric emptying and decreases small bowel transit time. Also increases prolactin levels. Therapeutic Effect (s): Improved GI motility. Decreased nausea/vomiting associated with dopamine agonist ...Ibogaine is a natural substance found in the root of a plant that grows in West Africa. In small amounts, ibogaine works as a mild stimulant, and people have been using it for a long time to fight tiredness, hunger, and thirst. When taken in larger amounts, it can create strong mind-altering experiences. Mark Fox/Getty Images.jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common ondansetron side effects may ...View topics in the Canadian Index section of Davis’s Drug Guide. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF.Find information on Amlodipine (Katerzia, Norliqva) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.DailyMed contains labeling for prescription and nonprescription drugs for human and animal use, and for additional products such as medical gases, devices, cosmetics, dietary supplements, and medical foods. The NLM provides DailyMed to the public and does not accept advertisements. The labeling on DailyMed is typically …Find information on Fluoxetine (PROzac, Sarafem) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Davis's Drug Guide. View topics in the All Topics A section of Davis’s Drug Guide. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Find comprehensive medical reference information including disease symptoms, diagnoses, treatments, and follow-up; plus drug and medication dosing, interactions, adverse effects, and more on Medscape, a free, comprehensive, and current resource for physicians and other healthcare professionals.2.8 Dosage in Plaque Psoriasis. The recommended dosage of Infliximab in adult patients is 5 mg/kg given as an intravenous induction regimen at 0, 2 and 6 weeks followed by a maintenance regimen of 5 mg/kg every 8 weeks thereafter for the treatment of chronic severe (i.e., extensive and/or disabling) Ps.May 18, 2022 · Davis's Drug Guide for Nurses is a game-changer for healthcare professionals. Packed with high-quality, easy-to-understand information, this compact guide is a powerhouse of accurate drug details. The hardcover adds a touch of durability, making it easy to carry anywhere. Davis’s Drug Guide App + Web powered by Unbound Medicine provides up-to-date information on 5000+ trade name and generic drugs. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF. Examples include 2.5 mL twice a day, one tablet three times a day, one injection every four weeks. The total daily dose is calculated from the dose and the number of times per day the dose is taken. The dosage form is the physical form of a dose of drug. Common dosage forms include tablets, capsules, creams, ointments, aerosols and patches.Davis’s Drug Guide delivers up-to-date, comprehensive, and practical information on over 5,000 trade names and generic drugs. This powerful resource contains everything you need to provide premium care to your patients including information on dosing and administration, safety, interactions, patient teaching, and much more.Oct 17, 2023 · Davis’s Drug Guide for Nurses and MDs delivers trusted, regularly updated information on more than 5,000 medications. Each drug monograph, with its focus on safety, includes details on pharmacokinetics, dosing, side effects, interactions, assessment, and more. Add Drug Interactions from The Medical Letter to your Davis’s Drug Guide app. trintellix formulation _____ highlights of prescribing informationMetoprolol is available as two different salts: metoprolol tartrate and metoprolol succinate. The main difference between metoprolol tartrate and metoprolol succinate is that metoprolol tartrate is only available as an immediate-release tablet which means it must be taken several times per day, whereas metoprolol succinate is an …Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for … Herbs and Supplements. Browse dietary supplements and herbal remedies to learn about their effectiveness, usual dosage, and drug interactions. Prescription and over-the-counter medication information is from AHFS® Consumer Medication Information, copyrighted by the American Society of Health-System Pharmacists (ASHP), Inc., Bethesda, Maryland ... Acknowledgments. We offer our thanks to the students and nurses who have used our book for more than 35 years. We hope our book provides you with the current knowledge of pharmacotherapeutics you need to continue to give quality care in our rapidly changing health care environment. April and Cindy. Option 1: Search for a drug. Sign in to MyHumana to search the list of drugs covered by your specific Humana Medicare plan and to price your medication. Sign in and search drug coverage. Or, use our search tool to look up the specific drug you need. It will tell you whether the drug is covered under your Humana plan, and provide alternatives ... Acknowledgments. We offer our thanks to the students and nurses who have used our book for more than 35 years. We hope our book provides you with the current knowledge of pharmacotherapeutics you need to continue to give quality care in our rapidly changing health care environment. April and Cindy. Davis’s Drug Guide for Nurses and MDs delivers trusted, regularly updated information on more than 5,000 medications. Each drug monograph, with its focus on safety, includes details on pharmacokinetics, dosing, side effects, interactions, assessment, and more. Add Drug Interactions from The Medical Letter to your Davis’s Drug Guide app.In 1998, FDA issued final regulations establishing requirements for the distribution of patient labeling for certain prescription drug and biological products used primarily on an outpatientThe best way to dispose of your expired, unwanted, or unused medicines is through a drug take back program. Or you can do it at home. Check the FDA flush list.Extended-release products are given once daily. MI: 25–50 mg (starting 15 min after last IV dose) every 6 hr for 48 hr, then 100 mg twice daily. Heart failure: 12.5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day. Migraine prevention: 50–100 mg 2–4 times daily (unlabeled).Find information on Fluoxetine (PROzac, Sarafem) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Redeem Your Book Code. This code gets you a FREE 1-Year subscription to Davis's Drug Guide - Web Only. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. iii ACKNOWLEDGEMENTS The expedited publication of this edition of the Primary Healthcare (PHC) Standard Treatment Guidelines and Essential Medicines List is testament of the enthusiasm,Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Benazepril (Lotensin) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Davis's Drug Guide - Nursing is an app that provides access to over 1,700 monographs on 5,000+ drugs, with audio pronunciations, pill images, safety alerts, and more. It also offers IV calculators, highlighting, note-taking, and alerts features, as well as a subscription to DrugGuide.com and Drug Interactions. iii ACKNOWLEDGEMENTS The expedited publication of this edition of the Primary Healthcare (PHC) Standard Treatment Guidelines and Essential Medicines List is testament of the enthusiasm,Eye drops, ear drops and some antibiotics are some examples of liquid medicines that aren’t safe to use past their expiration date. “Liquids easily become contaminated,” Dr. Hodes shares ...View topics in the Canadian Index section of Davis’s Drug Guide. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF.With FDA drug news and regular updates. DrugGuide.com, the online companion to Davis’s Drug Guide, provides trusted, easy-to-search content on the web. Search over 1,700 drug monographs and over 5,000 trade name and generic drugs with regular updates. $39.95. ADD TO CART.Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Benazepril (Lotensin) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Find information on Propranolol (Hemangeol, Inderal) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Guidelines for Prescription Medicines. The Australian Regulatory Guidelines for Prescription Medicines (ARGPM) assist applicants and sponsors to register new prescription medicines or vary existing registrations in Australia. Sponsors may now apply to register a prescription medicine under the provisional approval pathway, priority review ...Metoprolol is available as two different salts: metoprolol tartrate and metoprolol succinate. The main difference between metoprolol tartrate and metoprolol succinate is that metoprolol tartrate is only available as an immediate-release tablet which means it must be taken several times per day, whereas metoprolol succinate is an …By Madison Malone Kircher. April 19, 2024, 12:10 p.m. ET. When Taylor Swift released “The Tortured Poets Department,” on Friday at midnight, her fan base quickly …Find information on Albuterol (Accuneb, Proair Digihaler) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Decrease in ventricular response in atrial fibrillation or atrial flutter. Termination of paroxysmal atrial tachycardia. Find information on Digoxin (Lanoxin) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
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Newly Added Guidance Documents. Below is a sortable list of the most recently added Guidance Documents. You can sort alphabetically by: Category/Subject Area; Guidance Title; Guidance Type (Draft ...Drug Guide & Medication App delivers trusted, regularly updated information on more than 30,000 SKU of drugs approved by the U.S. Food and Drug Administration (FDA). Each …Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Sertraline (Zoloft) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.U.S.-based MDs, DOs, NPs and PAs in full-time patient practice can register for free access to the Prescribers’ Digital Reference on PDR.net. PDR.net is to be used only as a reference aid, it is not intended to be a substitute for the exercise of professional judgement.Metoprolol is available as two different salts: metoprolol tartrate and metoprolol succinate. The main difference between metoprolol tartrate and metoprolol succinate is that metoprolol tartrate is only available as an immediate-release tablet which means it must be taken several times per day, whereas metoprolol succinate is an …An access code inside new, printed texts unlocks your one-year, FREE 1-year subscription to DrugGuide.com, Davis’s Drug Guide Online, powered by Unbound Medicine, information on more than 5,000 trade names and generic drugs, as well as audio pronunciations and color photographs, all updated regularly. Drugs.com began licensing and displayed Physician's Desk Reference (PDR) drug information in 2003 and continued to publish PDR content until 2010. In mid-2010 a change in policy by the distributors of PDR resulted in the non-renewal of the licence and the removal of Physician's Desk Reference Consumer Drug Information from the Drugs.com website. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side …Action. Acts as a peripheral dopamine receptor blocker. Increases GI motility, peristalsis, and lower esophageal sphincter pressure. Facilitates gastric emptying and decreases small bowel transit time. Also increases prolactin levels. Therapeutic Effect (s): Improved GI motility. Decreased nausea/vomiting associated with dopamine agonist ...Find information on Pantoprazole (Protonix) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Try the app for 14 days! INSTALL. Skip to main content navigation Skip to main content. Find information on 5000+ drugs by name, dosage, side effects, interactions, and uses. Search by keyword or browse by category, such as combination, pharmacokinetics, or availability. Find information on Diazepam (Diastat, Valium) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Washington State University researchers have been awarded more than $370,000 for a two-year study into the impact of a controversial drug administered to …Treatment is indicated in patients with Paget’s disease of bone with elevations in serum alkaline phosphatase of two times or higher than the upper limit of the age-specific normal reference range, or those who are symptomatic, or those at risk for complications from their disease [see Clinical Studies (14.5)]..